It seems that a nasal spray with ketamine might become a solution for people with serious mental illness. At least this is what a clinical trial has showed. Apparently, the drug can tackle depression symptoms and suicidal thoughts. Some Yale University researchers and manufacturer of antidepressant esketamine, Janssen, observed a change in the symptoms of the patients deemed at high risk of suicide in just a few hours. The patients noticed this amelioration themselves. According to the trail, ketamine might be the immediate solution when conventional antidepressants take weeks to become effective.
The US Food and Drug Administration deemed esketamine a “breakthrough therapy” for people at imminent risk of suicide. This status is very important as it allows the development process to become quicker. There have been some previous trials which used intravenously injected ketamine However, this new one that uses a nasal spray is more effective and easy to administer. The researchers tested their theory on 68 patients at imminent risk of suicide. These people were also taking antidepressants. Randomly, the team assigned some to receive an esketamine spray twice a week for four weeks. Others only took a placebo replacement for the same period.
Ketamine might be the solution against suicidal thoughts
Neither the patients nor the doctors knew which people took the placebo and which took the esketamine. However, four hours after taking the esketamine dose and 24 hours after, the patients start feeling much better. There is a problem with antidepressants to day as most of them take up to six weeks to become effective. This is too much, and it can become a life and death situation.
And while esketamine seems t o be the way to go, it would be a struggle to keep people from overdosing on it. Some might use it as a form of recreational drug.
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