Now a lot of people know that the prevalence of kidney stone has increased abut 70% in the United States since the 1970s. For years, experts have wondered about the exact cause for these large numbers. Now, a new study, which the Journal of the American Society of Nephrology recently published, claims that the use of oral antibiotics might have played a key role in that. In order to reach this unusual conclusion, the team used health records from about 13.8 million patients of practitioners in the United Kingdom.
A number of 25,981 patients who were suffering from kidney stones were then matched for sex and age with about 259,797 controls. Before the diagnosis was established, the team followed their antibiotic exposure for three to 12 months. Before establishing their conclusion, the team also checked the patients for other diseases. Those included urinary tract infections, gout, diabetes and other variables, along with medications. Finally, they realized that exposure to any of the five classes of antibiotics drastically increased the risk for kidney stones.
Antibiotics exposure increases the risk for kidney stones
It seems that the worst were broad-spectrum penicillins, which increased the risk with about 27% along with sulfa drugs. These ones more than doubled the risk for kidney stones in healthy people. Moreover, it seems that when it came to children under the age of 18, the risks were significantly bigger. According to Dr. Gregory E. Tasian, the lead author of the study, it’s still unclear how exactly antibiotics make this possible.
However, his main idea is that the antibiotics interact badly with the gut or urinary microbiome. It’s a complex relationship that both benefits the patient while also posing some risks. This is why it’s important for antibiotics to be prescribed without increasing side effects in vain for the patient. Also, it may be a completely different cause that is yet to be discovered.
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